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Information × Registration Number 0214U007168, 0111U001882 , R & D reports Title Modelling and development of nanoconugates of anticancer action popup.stage_title Head Kovalenko Sergey Nikolaevich, Registration Date 05-05-2014 Organization Nation University of Pharmacy popup.description2 Objective: To design nanoconjugates based on the known anticancer agents given vector delivery anticancer agent to the cancerous tissue , as well as analysis of the structure of new nanoscale molecular structures , the rationale for their selectivity , the development of new concepts of operation , the selection of promising structures for drug development . Methods: chemical , pharmacological , physiological, physico-chemical, instrumental , computer modeling, optical and electron microscopy, methods of mathematical statistics . Held computer design nanoconjugates anticancer agents with carbon nanotubes (CNT ) . The interaction of the CNT with a number of cytotoxic cardiosteroids . The principal possibility of transport of anticancer agents , both inside and outside the CNT . Investigated the molecular- dynamic characteristics forming conjugates with angiogenesis inhibitors CNTs obtained functionalized CNT CNT investigated supramolecular complexes with phospholipids and other surfactants investigated the influence of CNTs on the cells of different tissues , depending on the features of their structure , developed methods for obtaining nanoconjugates angiogenesis inhibitors with liposomes developed methods of analysis such nanoconjugates. Obtain stable dispersions of CNTs in water, and examined their physicochemical and pharmacological performance. A computer simulation nanoconjugates metals as potential anticancer agents . Developed a framework for the creation of a number of drugs to treat the side effects of surgery , chemotherapy - and radiotherapy for cancer using nanoconjugates metals , obtained samples of medicines and studied their microbiological and pharmacological characteristics . Made fundamental work bіt can be used to create a number of new drugs , including anti-cancer effect5481 Product Description popup.authors Євсєєва Л.В. Гріщенко І.В. Губін Ю.І. Губарь С.М. Зборовська Т.В. Ковпак Л.А. popup.nrat_date 2020-04-02 Close