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Information × Registration Number 0214U007519, 0114U005325 , R & D reports Title Research and toxic food additive antioxidant action B-1, which is used in livestock and poultry. popup.stage_title Head Omelyanchik Ludmila Alexandrivna, Registration Date 29-10-2014 Organization Zaporozhye National University popup.description2 The first time the acute toxicity of feed additive B-1 was studied using tabular rapid method for determining the average effective measures influence on biological objects for VB Prozorovskii Results of acute toxicity study showed that the feed additive B-1 is relatively safe when administered intraperitoneally in a wide range of doses. The death of animals when administered the drug at a dose of 4000 mg / kg sposterahilasya they were alive and active at 12, 24 hours and 14 days. In mice is not affected by reflex activity, respiratory rate and depth. LD50 feed additive B-1 is 4560 ± 67 mg / kg Antioxidant activity of feed additives studied by 3 methods in vitro, which differ in the mechanism of initiation of free radical processes, substrates and oxidation products vyznachayemyh marker: study of antiradical activity (ARA) by inhibiting superoksydradykalu in the system autookysnennya adrenaline in adrenochrome for nitrogen monoxide and inhibition by model nitrozuyuchoho stress. Shown that the feed additive B-1 has a strong antioxidant activity. By inhibiting superoksydradykalu in the system autookysnennya adrenaline in adrenochrome showed that the feed additive B-1 shows high activity (52%) and the strength of the antioxidant effect exceeds (p <0,05) activity "Thiotriazoline" and "Emoksypinu." It is proved that the introduction in the incubation mixture before modeling nitrozuyuchoho stress feed additive B-1 at a concentration of 10-6 M leads to restriction of damaging aggressive forms of nitrogen monoxide relative SOD activity. Research results are implemented in the production process of small private enterprise "Selenga". As a result of research identified effective concentration of feed additive B-1 when feeding chickens. Product Description popup.authors Авксентьєв В.С. Веселков А.В. Завгородній М.П. Петруша Ю.Ю. popup.nrat_date 2020-04-02 Close