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Information × Registration Number 0214U007660, 0114U001676 , R & D reports Title "Obtaining of new polyfunctional derivatives of 1,3,5-triazine with a wide range of biological activity" popup.stage_title Head Polovkovych Svyatoslav, Кандидат хімічних наук Registration Date 25-12-2014 Organization Lviv Polytechnic National University popup.description2 A potential anticancer drugs by target synthesis of thiopyrano[2,3-d]thiazol-2-one derivatives with 1,3,5-triazine fragment using as a connecting bridge norbornene fragment were obtained. Using molecular docking of the molecule of 1,3,5-triazinecontaining thiopyranothiazolidones substituents were defined and synthesis of compounds, which predictably showed the highest degree of affinity to the biological targets and binding with which provides anticancer activity, were proposed. The methods and techniques for synthesis of 1,3,5-triazine derivatives were proposed and developed; the influence of temperature and solvent on the flowing of cyclocondensation reactions were studied and maximum yield of the product at the minimum material and energy costs was obtained, the study of their structure and physicochemical properties were carried out. By experimental studies of biological activity of obtained systems in vitro on cancer cell lines previously predicted anticancer activity of synthesized derivatives of 1,3,5-triazine was confirmed.5481 Product Description popup.authors Кархут Андрій Ігорович Ковальчук Олексій Іванович Кудрінецька Анастасія Вікторівна Литвин Богдан Ярославович Шах Юрій Ігорович popup.nrat_date 2020-04-02 Close