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Information × Registration Number 0214U008302, 0114U007284 , R & D reports Title Design and synthesis of novel functionalized chalcones as inhibitors of hemoglobin-degrading malarial cysteine proteases, falcipain 2/3 popup.stage_title Head Gorobets Nikolay Yurievich, Registration Date 25-12-2014 Organization State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine popup.description2 Aim of the work is reliable choice of a docking method and selection of the docking lead structures of chalcones for further in vitro studies. Methods: quantum-chemical calculations, statistic analysis, literary survey. A comparative analysis of two docking programs was carried out and one of them was chosen for docking-lead structures evaluation. Refining docking of chalcones - potential inhibitors of falcipain 2 was carried out, docking-lead structures were evaluated and recommended for futher synthesis and in vitro studies by indian side. Product Description popup.authors Водолаженко Марія Олександрівна Десенко Сергій Михайлович Зубатюк Роман Ігорович Седаш Юрій Володимирович popup.nrat_date 2020-04-02 Close