Search academic texts

Information × Registration Number 0214U008321, 0110U006169 , R & D reports Title The effect of cultured autologous cells on restoration of tendon structure under experimental tendopathy. popup.stage_title Head Goltsev Anatoly M., Registration Date 25-12-2014 Organization Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of the Ukraine popup.description2 The research object is cultured and сryopreserved of multipotent mesenchymal stromal cells in the bone marrow and skin fibroblasts, tendons. The research aim is to study of the location of cultured and cryopreserved autologous multipotent mesenchymal stromal cells of bone marrow and skin fibroblasts in degenerative damaged Achilles tendon at local introduction in dynamics. The research methods are cultural one, cryopreservation, experimental modeling tendinopathy, histological and immunofluorescence analysis. The results of the research work. The dynamics of localization of the cultivated and cryopreserved autologous multipotent mesenchymal stromal cells (AMMSC) of bone marrow and skin fibroblasts (ASF) in the therapy of degenerative damage Achilles tendon (AT), with the local introduction was investigated. Local administration of both cultivated and cryopreserved autologous сells in degenerative-dystrophic damaged AT 21 day observation led to the restoration of contour definition bundles of collagen fibers, increasing the number of cellular elements and area of type III collagen, indicating activation of regenerative processes in the damaged tendon. With fluorescent labels (PKH-26) shows the presence and introduced AMMSC ASF of the defect for 21 days. Product Description popup.authors Волкова Наталія Олександрівна Павлович Олена Володимирівна popup.nrat_date 2020-04-02 Close