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Information × Registration Number 0214U008334, 0114U007235 , R & D reports Title The study of molecular mechanisms of function and regulation of glutamate AMPA receptors under chronic inflammatory pain popup.stage_title Head Voitenko Nana Volodymyrivna, Registration Date 25-12-2014 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Persistent inflammation causes substantial changes in functioning of both synaptic and extrasynaptic AMPA receptors in SG neurons of the spinal cord. In particular, persistent peripheral inflammation produced dramatic increase in calcium permeability of AMPA receptor. Such increase in functional expression of Ca2 + permeable AMPA receptors occurs at synapses and in extrasynaptic membranes SG neurons of the spinal cord and plays an important role in the maintenance of thermal hyperalgesia in rats with peripheral inflammation. The molecular mechanism of increasing Ca2 + permeability of synaptic AMPA receptors in the spinal cord neurons based on the internalization of AMPA receptor GluR2 subunit caused by peripheral CFA-induced inflammation. Product Description popup.authors Білан Павло Володимирович Борисюк А.Л. Войтенко Нана Володимирівна Вятченко-Карпинский В.Ю. Грушевский Е. А. Довгань О.В. Дромарецкий А.В Дужий Д.Є. Едутенко М.Ю. Коляда Ю.М. Кононенко М.І. Кротов В.В. Сафтенку О.Е. Степанюк А.Г. Хомула Євген Валерійович Цугорка Т.М. Черкас В.П. Шеремет Е.Ю. Яценко В.П popup.nrat_date 2020-04-02 Close