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Information × Registration Number 0214U008363, 0114U004609 , R & D reports Title Enhancement of antineoplastic action of novel anticancer drugs: application of combined chemotherapy and improvement of drug delivery popup.stage_title Head Stoika Rostyslav Stepanovych, Registration Date 22-12-2014 Organization Institute of Cell Biology NAS of Ukraine popup.description2 Antineoplastic effect of new nanoscale delivery systems anticancer drug doxorubicin based on fullerene C60 was investigated in this study. It was shown that these C60-Dx complexes have shown high efficiency of their action both in vitro (towards different tumor cell lines) and in vivo (on murine Lewis carcinoma model), which was 1.5 -2 times higher than doxorubicin in free form. Antitumor effect of fullerene-doxorubicin systems was characterized by more intense induction of apoptosis in target cells compared to native doxorubicin, because of targeted delivery of doxorubicin towards tumor cells by C60 fullerene. The obtained results indicate on completely new physical and chemical properties of these nanocomposites, which are much more effective compared to parental compounds. The results of this study are published in one article in prestigious peer-reviewed journal. Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close