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Information × Registration Number 0214U008366, 0110U006326 , R & D reports Title Determination and characterization of molecular markers for evaluation of progression and treatment effectiveness of autoimmune disorders popup.stage_title Head Bilyy Rostyslav Olexandrovych, Registration Date 22-12-2014 Organization Institute of Cell Biology NAS of Ukraine popup.description2 During current stage of the project the impact of target cells desialylation with different agents (bacterial neuraminidase, abzyme with silidase activity and its F(ab)2 fragments) on the development of the immune response to allogeneic cells in vivo was determined to establish optimal therapeutic form of abzyme with sialidase activity. Anti-inflammatory and tolerogeneic effect of F(ab)2 fragments of abzyme on the immune response to allogeneic cells of laboratory mice in vivo was demonstrated. It was determined that the best therapeutic properties are achieved not in the full form abzyme, but in its F(ab)2 fragment. Product Description popup.authors Білий Р.О. Кіт Ю.Я. popup.nrat_date 2020-04-02 Close