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Information × Registration Number 0214U008442, 0114U006017 , R & D reports Title Landomycin A - a platform for the development of novel anticancer drugs popup.stage_title Head Ostash Bohdan Omelianovych, Доктор біологічних наук Registration Date 24-12-2014 Organization Ivan Franko National University of Lviv popup.description2 Objectives of work - to study regulation of production and mode of action of landomycin A (LaА). Work is focused on LaA producer Streptomyces cyanogenus S136 and cancer cell lines to be treated with LaA. Goal of research - to develop biotechnology for generation of subgram amounts of LaA and to study its mechanism of action on mammalian cells. Strains with extra copies of pleiotropic regulatory genes bldA, adpA were generated. Caspase 9 has been shown to play initiating role in LaA-induced apoptosis. Product Description popup.authors Білик Богдан Романович Громико Олександр Миколайович Осташ Ірина Степанівна Федоренко Віктор Олександрович popup.nrat_date 2020-04-02 Close