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Information × Registration Number 0214U008455, 0110U005759 , R & D reports Title Study of the role of S18 family mitochondrial proteins in the process of malignant transformation of cells popup.stage_title Head Kashuba Elena Vitaliivna, Доктор біологічних наук Registration Date 24-12-2014 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Was shown a new mechanism of cell cycle regulation involving mitochondrial ribosomal protein MRPS18-2 (S18-2). It is shown that over-expression of only one protein S18-2 in primary rat fibroblasts leads to imortalizatsiyi and cell transformation, and in some clones observed de-differentiation of cells, and other clones of transformed cells develop in immunodeficient mice fibrosarcoma in SCID. When imortalizatsiyi cells due to overexpression of the protein S18-2 change at least 19 cell ways to set with hybridization and quantitative PCR mikromasyviv. Among these ways NANOG and proliferation, oxidative phosphorylation, cell respiratsiyi and production of ATP. Karyotyping showed that overexpression of the protein caused by chromosomal instability S18-2. This testifies to the fact that the protein S18-2 is a product of oncogene and may serve as a target for anticancer therapy. Product Description popup.authors Бучинська Любо Георгіївна Гордієнко Інна Михайлівна Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна Юрченко Наталія Юріївна popup.nrat_date 2020-04-02 Close