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Information × Registration Number 0214U008782, 0114U005202 , R & D reports Title Development of the equipment for obtaining ion and X-ray microbundles using electrostatic accelerators and study of the radiation damages of the cells at the hadron therapy: a quantum-chemical investigation of the irradiated biological objects popup.stage_title Head Brovarets' Ol'ha Oleksandrivna, Registration Date 16-10-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Aim of the project - quantum-chemical study of the ionization processes that cause protonation on the conformational variability of the canonical 2'-deoxyribonucleotides, for the needs of medicine, molecular biophysics and cell biotechnology. Methods of investigation - novel methods, in particular quantum-mechanical (QM), of the computer simulation of a high level of complexity and Bader's topological analysis of the electron density (QTAIM). It is shown that the ionization mechanism of transitions does not guarantee any advantages over other mechanisms presented in the literature. However, the protonation/deprotonation of the bases of any canonical nucleoside significantly disturbs the DNA-like conformation of the latter. Product Description popup.authors Броварець Ольга Олександрівна Говорун Дмитро Миколайович popup.nrat_date 2020-04-02 Close