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Registration Number

0214U008999, 0113U001436 , R & D reports

Title

CD150/SLAM-family receptors: regulation of cell functions and possible clinical applications

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Head

Sidorenko Svitlana Pavlivna,

Registration Date

22-12-2014

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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For the first time it was shown that the profile of CD150 isoforms in cell lines of glial origin is different from hematopoietic cells, since they were characterized by high level of nCD150 expression and low level (or absence) of mRNA mCD150 isoform. with conventional cytoplasmic tail. In order to create the experimental model systems with expression of nCD150 and mCD150 isoforms, the set of experiments was started. It was shown that in the DT40 model system the mCD150-mediated signaling pathways led to ERK1/2 activation and did not affect the Akt activation. From cell lines DT40, U87 and A172 we have created experimental cell model systems expressing mCD150 and nCD150 isoforms and studied features of mCD150 and nCD150-mediated ERK1 / 2 and Akt signaling pathways, proliferative potential of U87 cells expressing surface CD150 receptor.

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Гордієнко І.М.
Ковалевська Л.М.
Романець О.Л.
Сидоренко С.П.
Шлапацька Л.М.