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Information × Registration Number 0215U000458, 0112U000523 , R & D reports Title Defining the role of hemostasis disorders in the development of systolic dysfunction in elderly patients with coronary heart disease popup.stage_title Head Korkushko Oleg Vasilievich, Registration Date 25-02-2015 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 Purpose. - Based on the definition of communication status indicators homeostasis of morphofunctional characteristics of the myocardium, the role of intravascular changes of systolic dysfunction in elderly patients with coronary artery disease and find out the possibility of improving the functional properties of the myocardium by affecting the performance homeostasis. Results. It is shown in patients with coronary artery disease in elderly heart failure progression is accompanied by systemic destructive changes in the myocardium, as evidenced by morphological characteristics of myocardial performance and increased titer autoantibodies cardiotropic. Reduction of myocardial contractility accompanied by elevated levels of aggregation activity of platelets and increase blood viscosity, which is an additional factor in the deterioration of tissue perfusion in CHF. According to the results in patients with ejection fraction <45% there is probably a lower growth rate of blood during the test with reactive hyperemia, indicating the presence of severe endothelial dysfunction in these patients. Analysis titer autoantibodies vaskulotropnyh showed that people with systolic dysfunction is a significant increase in titer AAt to PAPPA-A, ANCA, eNOS, plasminogen. It is shown that treatment with drugs that stabilize state hemovaskulyarnoho homeostasis (L-arhynin, pentoxifylline, tryfluzan, rheosorbilact) help to increase physical activity and improve quality of life in patients with CHF. Areas of use. Preventive and Clinical Medicine, gerontology, internal medicine, cardiology. Forms implementation. Patents, guidance, articles, reports. Product Description popup.authors Бенківська Наталія Миколаївна Бодрецька Лариса Анатоліївна Дужак Георгій Володимирович Жарінова Вікторія Юріівна Самоць Ірина Анатоліївна popup.nrat_date 2020-04-02 Close