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Information × Registration Number 0215U000679, 0110U005785 , R & D reports Title Metabolic engeneering of lipoglikopeptides antibiotic teicoplanin by Actinoplanes teighomyceticus popup.stage_title Head Shulga Sergiy Michaylovich, Кандидат фізико-математичних наук Registration Date 18-03-2015 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2 3. The recombinant molecules that provide increased expression of the genes adpAAT80 and bldDAT were constructed and the recombinant strains A. teichomyceticus with overexpression of gene of global regulators were obtained. In order to better manipulated with genes for teicoplanin production were search for new genes regulating the secondary of metabolism, recombinant DNA were constructed for transposon of mutagenesis, and it has been estimated possible use them in A. teichomyceticus. Strains of A. teichomyceticus with overexpression of the gene adpAAT80 have teicoplanin synthesize on the average is 2.4 times more than the parent strain under the same culture conditions. Overexpression of the gene adpAAT80 in cells A. teichomyceticus does not influence its morphogenesis. The transconjuganties of A. teichomyceticus adpAAT80 were selected with increased levels of teicoplanin synthesis. Product Description popup.authors Іващенко Т. Андріяш Г. Бейко Н. Громико О. Заболотна Г. Осташ Б. Прийомов С. Тігунова О. Ткаченко А. Федоренко В. Хоменко А. Шульга С.М. popup.nrat_date 2020-04-02 Close