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Information × Registration Number 0215U001209, 0112U005909 , R & D reports Title Development of different origin burns inhibition and treatment method by the volumetric auto transplontation of connective tissue cells compositions popup.stage_title Head Persriy E., Registration Date 03-02-2015 Organization Kharkov National University named after V.N. Karazin popup.description2 The research object - the dynamics of development and healing and decrease of local radiation burn development in guinea-pigs skin. The purpose of researches - development of the newest method of decrease of local radiation burn development and radiation ulcer by autotransplantation of fibroblasts and keratinocytes in the wound area, and use of dynamics of content of pro-, and anti-inflammatory cytokines in blood as an indexes of clinical flow, degree and prediction of healing of radiation burn. Methods of researches - cultivation of fibroblasts and keratinocytes, autotransplantation, histology, determination of concentration of interleukins. Results of researches - possibility of decrease development of local x-ray burn is well-proven for 3th degree by spasiouse autotransplantation of fibroblasts, or mixture of fibroblasts and keratocites. It was shown for guinea-pigs deep injection to the area of burn of auto cell in 1 hour, and then each 24 hours after an irradiation during 35 days substantially diminishes the sizes of damage, reduces the degree of inflammatory processes, formation of radiation ulcer decrease destruction of connective tissue matrix . Medical efficiency of autotransplantation by mixture of fibroblasts with keratinocytes substantially greater in comparing to autotransplantation only by fibroblasts. The research object - the dynamics of development and healing and decrease of local radiation burn development in guinea-pigs skin. he purpose of researches - development of the newest method of decrease of local radiation burn development and radiation ulcer by autotransplantation of fibroblasts and keratinocytes in the wound area, and use of dynamics of content of pro-, and anti-inflammatory cytokines in blood as an indexes of clinical flow, degree and prediction of healing of radiation burn. Methods of researches - cultivation of fibroblasts and keratinocytes, autotransplantation, histology, determination of concentration of interleukins. Results of researches - possibility of decrease development of local x-ray burn is well-proven for 3th degree by spasiouse autotransplantation of fibroblasts, or mixture of fibroblasts and keratocites. It was shown for guinea-pigs deep injection to the area of burn of auto cell in 1 hour, and then each 24 hours after an irradiation during 35 days substantially diminishes the sizes of damage, reduces the degree of inflammatory processes, formation of radiation ulcer decrease destruction of connective tissue matrix . Medical efficiency of autotransplantation by mixture of fibroblasts with keratinocytes substantially greater in comparing to autotransplantation only by fibroblasts. Product Description popup.authors К..Кот К.Морозова Л.Алтухова М.Гриценко Ю.Кот popup.nrat_date 2020-04-02 Close