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Information × Registration Number 0215U001248, 0111U009337 , R & D reports Title Develop method of stimulation of regenerative - reparative processes based on a combined use of growth factors, cellular and surgical techniques in plastic and vascular surgery. popup.stage_title Head Driuk Mykola, Registration Date 04-02-2015 Organization National institute of surgery and transplantology named after Shalimov O.O. of the Academy of Medical Sciences of Ukraine popup.description2 Methods of stimulation of regenerative-reparative processes and angiogenesis in ulcerative-wound tissue defects in patients with lower limb ischemia by combined use of transplantation autologon mononuclear bone marrow cells, graduate adipose tissue, platelet-rich plasma and traditional surgical interventions. Justified new approaches and algorithm combined use of cellular and surgical techniques of revascularization of tissue ischemia in patients with preconstruction forms of lesions of the extremities. Based on the use of cellular technologies and traditional surgical interventions developed new approaches and methods for the treatment of fibrotic transformation of the tissue at powermasters and trophic disorders of the legs in patients with chronic venous insufficiency and Dupuytren's contracture. Developed an experimental model in outbred rats in conditions of immunosuppression to study the effects of cellular technologies on the survival of transplanted adipose tissue and angiogenesis in ischemic tissues, without using expensive genetically modified animals. Found that transplantation of adipose aspirate or graft in combination with velenim mesenchymal stromlinie cells of adipose tissue (adipose tissue MSC) improves engraftment advocacv. The best result of survival advocacv transplanted fat aspirate is when enriching his MSC in adipose tissue and platelet-rich plasma. In experiments on rabbits the positive influence of autotransplanted in combination with Batp on the regeneration of autologous transplanted cartilage. The experimental results can be used as a preclinical stage clinical trials using auto-totransport in conjunction with MSC in adipose tissue in the treatment of tissue defects. Product Description popup.authors І.Є.барна І.В. Альтман І.М. Савицька А.Л. Петах В.Є.Євсєєв В.І. Кірімов ММ.Дрюк Р.В. Салютін С.Є. Гришай popup.nrat_date 2020-04-02 Close