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Information × Registration Number 0215U001430, 0110U006127 , R & D reports Title Development of the system for growth inhibition of brain tumors on the basis of nanoconjugates of antisens-oligonucleotides and antibody, specific for oncoproteins, with natural bioplymers popup.stage_title Head Kavsan Vadym Moiseevich, Registration Date 02-03-2015 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 In the in vitro experiments of transfection of human glioma U87MG cells it was shown the ability of CHI3L1-specific short interfering RNA (siRNA) and antisense morpholino-oligonucleotide to mRNA to inhibit production of CHI3L1protein. Nanoconjugates of CHI3L1-specific siRNA have inhibit also a production CHI3L1 protein. Suppression of CHI3L1production reduces the ability of ls to form colonies in U87MG soft agar that are evidenced about the decrease of cell malignancy level. Product Description popup.authors Єршов Антон Вікторович Балинська Олена Вікторівнв Дмитренко Володимир Володимирович Дубей Лариса Василівна Костенко ОЛександр Миколайович popup.nrat_date 2020-04-02 Close