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Information × Registration Number 0215U001646, 0110U007776 , R & D reports Title To study the peculiarity of tuberculosis in HIV-infected persons, to to develop the methods for improving of diagnostics and medical treatment popup.stage_title Head Korzh Olena Volodimirovna, Registration Date 09-04-2015 Organization State Medical University named after M. Gorky popup.description2 The widespread forms of tuberculosis prevailed at co-infected HIV/TB patient, multiply drugs resistance were 1,5 times more frequent, 62,0 % patients had CD4-lymphocytes count less than 200 cell/mcl. Majority of HIV-infected patients with tuberculous meningoencephalitis had the same clinic with non HIV-infected. There were an atypical clinical picture with absence of neurological symptom at patients with CD4 count less than 100 cell/mcl. With the high level of lethality from TM were associated immunosuppression, multiply drugs resistance, late diagnostics. Tuberculous meningoencephalitis had character of classic leptomeningitis with presence specific morphological changes in the brain-tunics in 66,7 % HIV-infected patients. In HIV-infected patients tuberculous exudative pleurisy was characterized by development of vast pleura effusions, often bilateral, by development of disseminated pulmonary tuberculosis. Primary multiply drugs resistance was registered more frequent, 3,1 times more frequent the hemorrhagic character of exufate and scanty cellular sediment were revealed. The structure of bone-joint tuberculosis did not differ from the traditional distributing, tubercular spondilitis predominated (50,8 %). The bones damage in HIV-infected persons had the specific character, there were no features conditioned by HIV-infestation. Starting ART during specific chemotherapy of tuberculous meningoencephalitis resulted in the decline of lethality on 41,0 % or in 6,4 times according indexes in the case per 100 patients-years. Product Description popup.authors Джеджеіа Тимур Вахтангович Лєпшина Катерина Олександрівна Мірошніченко Дмитро Станіславович Ряполова Тетяна Леонидівна Садовник Євгенія Єгорівна Тлустова Тетяна Володимирівна Шумляєва Таміла Михайлівна Юровська Катерина Ігоревна popup.nrat_date 2020-04-02 Close