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Information × Registration Number 0215U001704, 0112U002385 , R & D reports Title Optimization diagnostics and correction of vascular lesions in patients with hypertension combined with obesity by studying the functional state of the endothelium and genetic disorders. popup.stage_title Head Babak Oleg Ya., Registration Date 23-04-2015 Organization 3.Kharkov national medical university popup.description2 The dependence of the state of endothelial dysfunction and its effective correction in patients with hypertension combined with obesity based on phenotypic and functional. clinical, biochemical, immunological and genetic factors (gene polymorphism PPARG (Pro12Ala) and PPAR (Leu162Val)). Heavier violation of the state of the endothelium were observed in genotype Pro12Pro PPARG gene and genotype 162Val PPAR gene (alleles compared with Ala and Leu). The appointment of telmisartan and rosuvastatin in patients with gene polymorphism Pro12Ala PPARG gene was sufficient use of medicines in medium therapeutic doses. The results obtained in our study results allowed to offer personalized treatment strategies and prevention of endothelial lesions in patients with hypertension combined with obesity. Product Description popup.authors Андреєва А. Гопцій О. Грозна Л. Железнякова Н. Зайцева М. Зайченко О. Зелена І. Кліменко М. Масляєва Л. Молодан В. Молодан Д. Нестерцова І. Овчаренко Л. Панченко Г. Просоленко К. Степанова О. Супрун С. Тельнова С. Фролова Е. Ярмиш Н. popup.nrat_date 2020-04-02 Close