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0215U001714,
0113U001276
,
Structural and metabolic changes in the cortex of the brain, kidney and liver caused by chronic neoplastic intoxication and components of cytostatic therapy, and their sorption correction
Lisnychuk Natalia Yevgenivna, Кандидат біологічних наук
27-04-2015
Ternopol State Medical University by I.Ya.Horbachevsky
Chronic neoplastic endotoxicosis causes activation of free radical oxidation processes, increased accumulation of its toxic metabolites in blood, enzymatic and non-enzymatic imbalance of AOS links. After admistration of cytostatic drugs chronic oncogenic intoxication is accompanied by more pronounced accumulation of toxic lipid peroxidation products and deepening links imbalance of antioxidant system. Under the oxidative stress dimethylhydrazine-induced carcinogenesis activates CD3-lymphocytes apoptosis and necrosis in peripheral blood and liver tissue, which is associated with lipid peroxidation products inhibition of mitochondrial respiratory chain and activation of ROS excessive formation. Induction of pronounced immune deficiency by depleting cellular and humoral immunologic resistance factors, as well as a significant increase of circulating immune complexes content and pro- and anti-inflammatory cytokines concentrations. Under condition of dimethylhydrazine-induced carcinogenesis and development of chronic neoplastic endotoxemia, liver undergoes significant morphological changes. Plethora of many vessels, especially of the central and underlobular veins, significant dilatation of the sinusoid capillaries lumen are combined with violation of orderly arrangement of hepatocytes in the lobules, especially in their periportal areas. Swelling of the stromal connective tissue and its leukocytic infiltration are occurred. The application of chemotherapy components enhances the changes in the vessels and hepatic parenchyma. Disturbances of organ girder and lobular structure is observed, necrotic hepatocytes are evident in intermediate and periportal areas. Irreversible destruction of hepatocytes occurs under significant vascular disorders and violations of transcapillary exchange and it essentially affects on the course of metabolic processes in the liver. The application of enterosorbent Carboline for correction the experimental neoplastic process under the chemotherapy treatment reduces extent of morphological abnormalities of structural components in experimental animals. Application of carbon sorbent Carboline promotes decrease of toxic and metabolic loads to organ of excretion and detoxication, corrects melabolic processes, promotes restoration of barrier, exerts a positive effect on factors of cellular and humoral immunity.
Демків Ірина Ярославівна
Калінічук Любов Олександрівна
Небесна Зоя Михайлівна
Чихира Ольга Володимирівна
2020-04-02
Updated: 2025-12-07
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