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Information × Registration Number 0215U001803, 0114U003779 , R & D reports Title Development, obtaining and pharmacological studies of promising series of pyrazolo-, thieno- and pirroloisoquinoline kinase inhibitors as universal regulators of energy metabolism popup.stage_title Head Popov Anatolij Fedorovich, Доктор хімічних наук Registration Date 20-05-2015 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 The object of study - functionally substituted pyrazolo [3,4-c] isoquinoline and thieno [3,4-c] isoquinoline, methods for their preparation and response. objective of the work to develop methods for functionally substituted and heteroannulated isoquinolines and library screening compounds for anticancer activity with a view to finding low-toxic targeted kinase inhibitors. Methods - organic synthesis, NMR, IR spectroscopy, thin layer chromatography and volume. A general method for the synthesis of glycosides aglycone class pyrazolo [3,4-c] isoquinoline, alkylation reaction can heterocycle heteroatoms N-acetyl-a-D-glucozaminylchloride in terms transphaze catalysis. The difference in reactivity nucleophilic centers pyrazolo [3,4-c] isoquinoline was found. Based on the analysis of experimental data for specific biological activity of heterocondensed isoquinoline, using modern modification Pictet-Spengler synthesis the target library thieno [3,4-c] isoquinoline derivatives was synthesized for the primary biological screening. Product Description popup.authors Богдан Наталя Михайлівна Богза Сергій Леонідович Зінченко Софія Юрієвна Пендюх Вячеслав Володимирович Суйков Сергій Юрійович Хижан Олександр Іванович Хилько Світлана Леонідовна Чотій Костянтин Юрійович popup.nrat_date 2020-04-02 Close