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Information × Registration Number 0215U002237, 0110U005317 , R & D reports Title New biochemical approaches for evaluation of metallic nanoparticles ecotoxicity based on determination of metallothioneins characteristics in water animals popup.stage_title Head Stoika Rostyslav, Registration Date 03-03-2015 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 A multymarker (more than 30 indicators) molecular analysis of functional state of the bivalve mollusk Anodonta cygnea, Prussian carp Carassius auratus gibelio and lake frog Rana ridibunda was performed and the role of metal depositing proteins metallothioneins (MT) in response to cobalt- and zinc-containing nanomaterials (Co -NM and Zn-NN) as well as their constituent ions of cobalt (Co), zinc (Zn), polymeric carrier (vinyl pyrrolidone derivative, MO) in an environmentally and/or real physiological concentrations. Data specific to each type of ability to remove metal ions from the nanocomposite, as well as the level and specific toxicity of the metal and its nanomaterials depending on the type of organism were first time received. The mechanism of fish MT participation in the molecular response to nanomaterials, depending on their nature was revealed for the first time. Manifestations specific to the effects of Co, Zn, Mo were clearly established and signs of free metal ions toxicity (based on the increase of hepato-somatic index) were proved. For the first time the ability to accumulate zinc and cobalt with nanomaterials by amphibians MT was described. As a result of the project, a new biochemical approach for biological indication and ecotoxicity evaluation of metal-containing nanomaterials in aquatic environments based on analyzing the functioning of aquatic animals' metallothioneins, metal depositing and stress proteins, was established and practical recommendations based on the use of aquatic animals' metallothioneins for early detection and differential cytotoxicity metal-containing nanomaterials were proposed. Product Description popup.authors Корчинський Олександр Геннадійович Стойка Ростислав Стефанович Столяр Оксана Борисівна Фальфушинська Галина Іванівна popup.nrat_date 2020-04-02 Close