Search academic texts

Information × Registration Number 0215U003154, 0114U001095 , R & D reports Title To define the cellular-molecular mechanisms of forming imunopathologiс processes for patients with the diseases of the blood system of myeloid origin popup.stage_title Head Gordienko A.I., Registration Date 22-01-2015 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Research object is peripheral blood cells (PC) and bone marrow (BM) of 71 patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) before and after the treatment The purpose is to study the basic parameters of antitumor immunity in patients with various forms of MDS and AML with newly diagnosed and after therapy. Methods: clinical, haematological, immunological. Found that in patients with АML, refractory anemia with excess blasts (RAЕB) and chronic miyelomonoсytik leukemia (СMML) before treatment significantly reduced the number of CD19 + - lymphocytes, CD3 + lymphocytes, CD3 + CD4 + -, CD3 + CD8 + - immunoregulatory subpopulations, CD8 + CD28 + killer T-cells, CD16 + CD56 + -, CD3 + CD16 + CD56 + - cells, which leads to an imbalance reactions antitumor immunity. In patients with СMML and АML in serum levels observed a significant decrease in IL-4, IL-8, IL-10, TNF-alpha and increasing - IL-1alpha, IL-2, IL-6, which constitutes a violation of the functional activity of immunocompetent cells that are involved in the production of these cytokines. Medicine. Product Description popup.authors Гордієнко А. .І. Горяінова Н.В. Загоруйко Н.Л. КисельоваО.А Кубарова В.О. Перехрестенко Т.П. Третяк Н.М. Шороп Є.В. popup.nrat_date 2020-04-02 Close