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Information × Registration Number 0215U003155, 0114U001096 , R & D reports Title Study of polimicrobial associations of biotops and immune violations at patients with the diagnosed infectiously-inflammatory complications at myeloid origin leukemia popup.stage_title Head Rybalska A.P., Registration Date 22-01-2015 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Objects: There were 31 patients, among them: 20 patients with AML, 1 - with MDS, 8 - with CML, 2 - with myeloproliferative disease; 148 strains of microorganisms. Aim: to improve diagnosis of infectious-inflammatory complications caused by etiological and persistent pathogens in myeloid leukemia patients. Methods: clinical, haematological, immunohistochemical, microbiological, immunological. Results: Infectious complications were observed in 73,7% of patients with cytopenia of different genesis: one branch cytopenia (anemia or leucopenia) was determined in 50,0% patients, two branches cytopenia - in 28.6% patients, three branches cytopenia - in 21,4% patients. The most common pathogens in AML patients with infection's complications were: Staphylococcus, which caused pneumonia, sinusitis, rhinitis and stomatitis (28,0% of the cases); Enterococcus which leads to pneumonia, bronchitis, sinusitis (24,0% of the cases); Candida, which caused mycosis lesions of mucous membranes in the mouth, throat and esophagus (16,0% of the cases). Staphylococcus, Moraxella, Enterococcus and Candida, which were revealed in diagnostically significant titers in biotopes from nose cavity and pharynx, are most possible cause of infection's complications in CML patients. The presence of pathogenic factors in IIC factors, determined by their sensitivity to antibacterial and antifungal agents. Was found some immune violations in AML and CML patients who had infection-inflammatory complications, such as: 1,5-2 times arising of IgM in the blood and reduce of completion of phagocytosis, increased levels of CRP up to 12-72 mg/l. The investigation's results improves the diagnosis of infectious-inflammatory complications which leads to promptly and appropriate prescribing of antibacterial and antifungal therapy in patients with myeloid leukemia. Medical and social effect. Medicine. Product Description popup.authors Кисельова О.А. Мельник О.А. Немировська Л.М. Перехрестенко Т.П. Скачкова Н.К. Третяк Н.М. Федоровська О.О. popup.nrat_date 2020-04-02 Close