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Information × Registration Number 0215U003372, 0113U003041 , R & D reports Title The use of natural antioxidants and products of nanotechnology as a neuroprotective in adverse environmental and metabolic disorders popup.stage_title Head Ushakova Galyna Alexandrovna, Доктор біологічних наук Registration Date 28-01-2015 Organization Dniepropetrovsk national university popup.description2 The object of study - the central nervous system of mammals. Purpose - to study both molecular and biochemical basis underlied in specific functions of the nervous system, including learning and memory, search neuroprotective agents that can prevent the violation of cognitive function in human under anthropogenic stress treatment. The research used with modern biochemical, physical, chemical and statistical methods, computer data processing. There is performed test system for determination the content of glial fibrillar acidic protein and myelin basic protein (sensitivity of 3 to 100 micrograms in 0.1 ml volume analytical sample 250 ml). The test system is designed according to the requirements of rapid methods (duration of the entire protocol analysis is 3 hours). New data received for the first time on the distribution of glial fibrillar acidic protein in different brain regions of rats in experimental nonalcoholic steatohepatitis, experimental chronic hepatitis and chronic pancreatitis; development of experimental chronic pancreatitis significantly affect the operation of the various structural parts of the brain. An intoxication leads to brain pathology and associated with the increasing of calcium-binding protein S-100b that as result leads to depolymerization of intermediate filaments. This is confirmed by the redistribution between soluble form glial fibrillar acidic protein (GFAP) and its filaments form. Treatment with natural antioxidant alpha-ketoglutarate decreased risk redistribution astrocytes specific proteins under both liver and pancreatic diseases. It was shown for the first time the possibility of the use of alpha-ketoglutarate as remedial drug in the hepatic and pancreatic encephalopathy. There is determined for the first time experimentally the influence of the introduction of nanoparticles hydrated fullerene C60 on the characteristics of the learning process in rats with STZ-diabetic yndukovanym and expression and polypeptide composition GFAP in several brain structures. The research results can be used in clinical medicine, to develop new test-system Product Description popup.authors Бабець Ярослава Вікторівна Кириченко Світлана Василівна Ковальчук Юлія Петрівна Макарчук Вікторія Анатоліївна Недзвецький Віктор Станіславович Прищепа Ірина Володимирівна Цуркан Олександр Михайлович Щербина Тетяна Володимирівна popup.nrat_date 2020-04-02 Close