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Information × Registration Number 0215U003380, 0110U005966 , R & D reports Title Study of nanostructurous calix[4]arenes for biomedical use as antithrombotic agents. popup.stage_title Head Lugovskoi Eduard Vitaliyovych, Registration Date 28-01-2015 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Calix[4]arene methylene bisphosphonic acid C-192 and its sodium salt C-145 were shown to be efficient inhibitors of fibrin polymerization in vitro (ІС50 was 0,5 10-6 М and 4 10-6 М respectably). After 4 hours after intravenous injection of calix[4]arene C-145 to rabbit the thrombin time and activated partial thromboplastin time were prolonged in 2 and 1,5 times respectively. Other parameters of coagulation and fibrinolysis remained constant. Calix[4]arene C-145 also strongly affected platelet aggregation induced by ADP and provoked thrombocytopenia. So we assumed that effects of calix[4]arene C-145 on haemostasis in vivo consists in selectively inhibition of fibrin polymerization and formation of three-dimensional fibrin network that is the core of thrombus. Product Description popup.authors Є.М. Макогоненко І.М. Колесникова В.І. Мищенко В.О. Наврулін В.О. Чернишенко Г.І. Горідько Г.К. Березницький Г.К. Гоголінська Д.С. Корольова Л.М. Литвинова Л.П. Урвант М.О. Пидюра Н.Е. Луговська О.В. Горницька О.П. Костюченко С.В. Комісаренко С.О. Черенок Т.А. Позняк Т.М. Платонова Т.М. Чернишенко popup.nrat_date 2020-04-02 Close