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Information × Registration Number 0215U003388, 0110U005963 , R & D reports Title Molecular mechanisms underlying the enhanced activity of plasminogen activation system components under carcinogenesis popup.stage_title Head Samoylenko A.A., Registration Date 28-01-2015 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The novel mechanisms of plasminogen activator inhibitor-1 (PAI-1) and urokinase (uPA) action that determine the control of proliferative and invasive properties of cells were established. Identification of proteins involved in the regulation of oxygen-dependent expression of plasminogen activation system components via interaction with HIF-1alpha and/or PHD1-4, together with ascertainment of surface urokinase receptor partner proteins, opens the possibility of search for antagonists of these interactions and development of pharmaceuticals aimed at blocking of urokinase effects. Such substances are of great necessity to medical practice, as plasminogen activation system components play major regulatory role in blood vessel remodeling and malignant cells' metastasis. Product Description popup.authors Дробот Л.Б. Козлова Н.В. Петухов Д.М. popup.nrat_date 2020-04-02 Close