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Information × Registration Number 0215U003401, 0110U005968 , R & D reports Title Cells isolated as spheroids from stable tumor cell lines and expressing certain stem cell markers as models to study the mechanisms of carcinogenesis and for developmnet of anticancer pharmaceuticals popup.stage_title Head Drobot L.B., Registration Date 29-01-2015 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The new data that demonstrate the involvement Rukl/CIN85 adaptor protein in the development and sustaining of cancer stem cells potential on models of human breast adenorcinoma cell line MCF-7 and rat pheochromocytoma cell line РС12 were presented. The created in vitro models may be used for screening, determination and characterisation of presently unidentified molecluar components of signal transduction pathways that are involved in control over critical sides of functional activity of cancer stem cells in carcinogenesis, and for establishment of the molecluar mechanisms underlying their activity. It is one of the most important problems that the modern cellular biology and fundamental medicine are facing, aimed at the search and development of antitumor pharmaceutical preparations able to selectively eleiminate cancer stem cells. Product Description popup.authors Биць Н.В. Горак І.Р. Пасічник Г.В. Петухов Д.М. Поворознюк О.О. Самойленко А.А. popup.nrat_date 2020-04-02 Close