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0215U003652,
0110U006126
,
New molecular genetic markers for gene expression signatures of brain tumors and their interaction with signaling pathways
Kavsan Vadym Moiseevitch,
12-03-2015
Institute of Molecular Biology and Genetics of NASU
The study for identification of gene expression signatures of brain tumors and characterization of identified new molecular genetic markers of glial tumors in their interaction with cellular signaling pathways is performed. The signature of glioblastoma gene expression is developed that can be used for diagnosis. The cell culture was obtained with stable expression of CHI3L1 oncogene, that significantly increases its expression in human gliomas, i.e. a model system is obtained that allows a testing of anticancer agents. The new tumor suppressor gene (TSC22) is characterized that inhibits the proliferation of cells, a recombinant protein TSC22 is obtained. It was shown that stochastic instability and chromosomal copy number variation in chromosome loci after exposure of cells to various stress factors specifically affected the specific indicators of malignant transformation.
Авдєєв Станіслав Сергійович
Арешков Павло Олександрович
Балинська Олена Вікторівна
Букреєва Тетяна Василівна
Дмитренко Володимир Володимирович
Кавсан Вадим Мусійович
Степаненко Олексій Анатолійович
Чаусовський Тімур Йосипович
2020-04-02
Updated: 2025-12-07
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