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Information × Registration Number 0215U003866, 0113U000067 , R & D reports Title To estimate influence of inflamatory and metabolic risk factors of cardio-vascular diseases on the flow of essential hypertension from data of the proctracted supervision to improve going near its second prophylaxis popup.stage_title Head Svishchenko Yevgeniya Petrivna, Registration Date 15-05-2015 Organization National Scientific Center "Institute of cardiology by M.D. Strazhesko Ukrainian Academy of medical scieces popup.description2 Report about NIR of 118 p., 39 tables., 1 appendix, 33 picture. A research object is essential hypertension (EH), factors of risk of cardio-vascular complications, organs-targets. Purpose of work - for patients to study intercommunication of long-term dynamics of the state of organs-targets hypertensive illness, in particular heart and brachiocefal arteries with the metabolic and proinflammatory factors of risk, influence of antigipertenziv preparations on the function of heart. Research methods - clinical, biochemical, echocardiografy, dopplerechocardiografy, day's monitoring of blood pressure (BP), full-duplex scan-out of vessels, patomorfological on the model of renovascular hypertension on the rabbit of breed chinchilla. It is well-proven that intensification of free-radical reactions for the patients of EH initiates processes (modifications of albumens, lipids, violation of permeability of membranes, intensification of autoimmune processes and other) which result in the defeat of organs-targets. The shown of signs of oxidizing stress in an end influences on the long-term dynamics of index of mass of myocardium of the left ventricle (LV). Factors development of diastolic disfunction of LV, are set for the patients of EH, the predictors of its progress are selected (insufficient control is BP, violation of his day's rhythm, hypertrophy and concentric changes of LV, hyperinsulinemia). Korregiruyuschee influence of row of antigipertenzivnykh preparations and their combinations is well-proven on the diastole function of LV in hypertensive patients. The model of Renovascular Hypertension is developed on rabbit (a request is given on an invention). GIPERTONITCHESKAYA ILLNESS, DYNAMICS of DEFEAT of ORGANS-TARGETS, LEFT VENTRICLE, CAROTIDS, BUDS, RISK FACTORS Product Description popup.authors Купчинська Олена Георгіївна Орлова Ніна Миколаївна popup.nrat_date 2020-04-02 Close