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Information × Registration Number 0215U004022, 0113U006037 , R & D reports Title Changes of phase state of lipidic bilayer as one of the factors of bioactive substances' activity. popup.stage_title Head Kasyan Nataliya Oleksandrivna, Registration Date 29-01-2015 Organization Scientific-research department of alkali halide crystals with experimental manufacture STC "Institute for single crystals" NAS of Ukraine popup.description2 It has been shown that cryoprotectors of the OEGn group can "replace" the water during dehydration of the lipid membrane, at the same time the melting peak remains up to ~ 100 wt. % of OEGn. The temperatures of the phase transitions of lipid membrane increase with the concentration of OEGn in the subphase; OEGn = 5 (30 wt.%) leads to the formation of the interdigitated phase. It has been shown that the investigated antitumor substances (CCЕ, doxorubicin, landomycin E) behave as typical membranotropic agents, decreasing the melting temperature of the lipid membrane. Product Description popup.authors Краснікова А.О. Міненко С.С. popup.nrat_date 2020-04-02 Close