Registration Number
0215U004767,
0111U003343
, R & D reports
Title
Study of infectious disease trigger on immunological mechanisms of autoimmune reactions formation
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Head
Protchenko Pavel Zakharovich,
Registration Date
01-12-2015
Organization
Odessa State Medical Universitu
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Large-scale investigation (4235 patients) for presence of autoantibodies in different autoimmune diseases (systemic lupus erythematosus (SLE), scleroderma (SCl), dermatopolymyositis (DPM), Sj?gren's syndrome (SS), rheumatoid arthritis (RA) was done. Seropositivity for hepatitis B and C, parvovirus B 19 and T.gondii was authentically higher in patients with confirmed autoimmune diseases than in control group. Authenticable increasing of ?-globulins levels and decreasing of albumins were registered in patients with autoimmune diseases; normalization of ratio of protein fractions was a marker of remission. For the first time in Ukraine it was shown authenticable increasing of IL-17 levels in blood serum of patients with SLE, SS, DPM and decreasing in patients with SCL, in addition level of IL-17 was authentically higher in patients, infected by hepatitis B and C (р < 0,05). Secondary antiphospholipid syndrome was developed in 37,2 % of patients with autoimmune diseases, the highest rate was registered in patients with SLE (57,7 %), the lowest - with SCL (16,0 %). Combined use of biochips with Hep-2 cells and protozoa C. luciliae was proposed for IFA in examination of patients with SLE.
Product Description
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Боровик Альона Петрівна
Кольцова Ірина Генадіївна
Протченко Павло Захарович
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2020-04-02
