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Information × Registration Number 0215U004920, 0115U003830 , R & D reports Title The study molecular mechanisms of anesthesia induced opioid analgesics. popup.stage_title Head Savotchenko (Savrasova) Alina Volodymyrivna, Registration Date 21-12-2015 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 At this stage of the project by "patch-clamp" was investigated the dependence of the concentration of the opioids on the activity of the P2X3 receptors and ion channels, which are expressed in neurons of the CNS and peripheral sensory ganglions. On isolated dorsal ganglion neurons and cerebellum cells of rats was established the type of opioid receptor, activation of which runs analgesic mechanism. Established that agonists in nanomolar concentrations can cause potentiation of the P-type of calcium current through interaction with ?-opioid receptors. Product Description popup.authors Єгорова Олена Володимирівна Кулик Вячеслав Борисович Савотченко (Саврасова) Аліна Володимирівна popup.nrat_date 2020-04-02 Close