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Information × Registration Number 0215U006019, 0112U001099 , R & D reports Title To study the pathogenetic mechanisms of pulmonary hypertension in chronic obstructive pulmonary disease (COPD) in combination with coronary heart disease (СHD). popup.stage_title Head O. Krakhmalova, Registration Date 23-01-2015 Organization Government institution "L.T. Malaya Therapy Institute National Academy of Medical Sciences of Ukraine" popup.description2 Object of study - 195 patients with COPD combined with coronary artery disease, patients with coronary artery disease and COPD.The aim - to study pathogenic aspects of the syndrome of pulmonary hypertension in patients with chronic obstructive pulmonary disease and concomitant coronary artery disease, develop clinical and diagnostic algorithms detect and identify therapeutic approaches to its prevention and correction. Methods: general clinical research spirography, echocardiography, pulsoksymetriya, the definition of clinical blood, questionnaire using the scale MRC, debt, the samples from the 6-min walking, determination of stable metabolites of nitric oxide, platelet aggregation, osteopontin levels, brain natriuretic peptide , interleukin 2.4. The established pathogenetic mechanisms of pulmonary hypertension (LH) in patients with COPD combined with coronary artery disease, the clinical course of LH in patients with COPD combined with coronary artery disease. The changes of biochemical parameters responsible for vascular homeostasis in patients with COPD and CHD, defined in their dynamics and progression stages of LH. Studied the diagnostic and prognostic value osteopontin, brain natriuretic peptide, interleukins. The features of cardiac remodeling and changes in hemodynamic parameters at the stages of LH in patients with COPD, CHD established contribution to the development of the process. Schemes LH treatment in patients with COPD and concomitant coronary artery disease, in order directed at correcting pathogenic and hemodynamic parameters. Product Description popup.authors Ємельянова Н.Ю. Єфімова Н.В. Антонова І.В. Бондар Т.М. Васильєв О.О. Висоцька О.В. Грідасова Л.М. Зоренко Н.В. Калашник Д.М. Колеснікова О.М. Коротченко О.В. Остапюк О.С. Попович А.С. Самохіна Л.М. Харченко Ю.Є. Цедрик Л.А. popup.nrat_date 2020-04-02 Close