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Registration Number

0215U006060, 0111U010491 , R & D reports

Title

The determination of the maternal stress influence upon the sensitivity to leptin as the link of the obesity and osteopathies pathogenesis in offspring (experimental study)

Head

Sergienko Lorianna Yu.,

Registration Date

30-01-2015

Organization

State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine"

Description

Object of research - experimental animals (rats) - offspring of different ages obtained from intact and gestational stressed mothers. Purpose - to establish the existence of changes effect in leptin on food intake, structure and function state of the endocrine glands and histological structure of tubular bones in adult animals , which stressed during the embryonic period; determine the association of the syndrome changes in sensitivity to leptin neuroendocrine regulation centers and peripheral tissues in the offspring of stressed mothers with gestational development of their obesity and Osteopaths. In work we used pathophysiological, histological, gravimetric, morphometric, immuno, statistical methods. Equipment used: different accuracy class scales, centrifuges, thermostats, microtomes, light microscope "Primo Star" with the camera Canon G 10. It was found that the socio-emotional stress of mothers in the first trimester of pregnancy leads to the birth of offspring with underweight and low plasma leptin. At the reproductive young age of offspring inherent in such a high growth rate of body mass and obesity associated with the formation of "economic type" energy expenditure in these animals. By the injection of exogenous leptin analog to offspring of gestational stressed mothers determined that they have leptin resistance by the hypothalamic centers of regulating the body's energy security, which is manifested through otsutstivie anorexia-gene effects in hyperprolactinemia. At the same time, hyperprolactinaemia not affect on sensitivity to the cytokine peripheral tissues such as cartilage and bone, as evidenced by potentiating effect of leptin on the reparative effects of estrogens with respect to the tubular bone in ovariectomized offspring when co-administered estrogen, and leptin. In this paper it proves also enhances the effect on the development of obesity excess revenues of fructose in the body of stressed offspring. The results obtained experimentally substantiate the need for measures to prevent gestational stress of mothers as the cause of obesity and osteopathy in the offspring, as well as the injection of the definition of leptin levels at birth to allocate risk groups for development of these pathologies. Scope: neonatology, рediatrics, endocrinology, internal medicine, family medicine.

Product Description

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Бастригіна Алла Олександрівна
Бондаренко Тетяна Вікторівна
Бурма Тетяна Юхимівна
Завадська Наталія Володимирівна
Маракіна Ганна Володимирівна
Перець Олена Вікторівна
Селюкова Наталія Юріївна
Сергієнко Лоріана Юріївна
Сидорова Ірина Василівна
Толмачова Любовь Миколаївна
Черевко Ганна Миколаївна