Search academic texts

Information × Registration Number 0215U006286, 0113U000262 , R & D reports Title To study the mechanisms of development of metabolic disorders and work out the possibility of their correction in the experimental pulmonary edema popup.stage_title Head Korzhov Vitaliy, Доктор медичних наук Registration Date 05-01-2016 Organization SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine" popup.description2 Object - blood of white rats with experimental pulmonary edema (PE). Aim - to find violations of the state of glutathione-dependent detoxicational and oxidant-antioxidant systems of blood and to justify the possibility of pharmacological therapy in experimental PE. Methods - experimental, biochemical, histological, statistics. Under the experimental PE condition activation of lipid peroxidation, homeostasis violation of glutathione dependent enzyme system, increasing the sorption capacity of red blood cells, the accumulation of endogenous intoxication markers - the average molecular weight were established. Identified biochemical violations depend on the adrenaline dose and the times elapsed after the pathology simulation, and have a maximum intensity changes at a dose of epinephrine 1,5 mg/kg body weight. The possibility of using sodium succinate and succinic acid drugs (meksydol, reamberin) to reduce endogenous intoxication, normalization of lipid peroxidation, increase the strength of cell membranes, lutathione-dependent activation of the blood system in experimental PE. Established that studied the impact of drugs on biochemical signs of pulmonary edema has different degrees of severity at different doses of adrenaline. Sphere of application - pulmonology Product Description popup.authors Жадан Вікторія Миколаївна Касьян Наталія Анатоліївна Коржов Віталій Іванович Лоза Тетяня Василівна Мельник Ольга Олександрівна Русінчук Ярослав Іванович popup.nrat_date 2020-04-02 Close