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Information × Registration Number 0215U007158, 0113U002327 , R & D reports Title Study of the metabolic changes and persisting infections influence of the nonalcoholic fatty liver disease in irradiated persons for improvement diagnostics and prognosis popup.stage_title Head Chumak Anatoliy Andreevich, Доктор медичних наук Registration Date 16-02-2015 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 The study of metabolic processes in patients with nonalcoholic fatty liver disease with different radiation history. The objective was to determine the characteristics of metabolic changes in patients with nonalcoholic fatty liver disease, who have been exposed to ionizing radiation as a result of the Chernobyl accident. When performing research were applied clinical, immunological, laboratory and instrumental methods of investigation. Equipment: ultrasonic devices Shiwadzу 410 B, Aloka - 2000, Aloka - 650, gastroscope Olympus (all manufactured in Japan), personal computers. The features of metabolic changes in non-alcoholic fatty liver disease as affected by the Chernobyl accident (main group) and patients in the comparison group (II HS): increased incidence of elevated total cholesterol (75,7 % and 64%) and beta-lipoproteins (58,9 % and 44%), significantly higher average cholesterol and beta-lipoproteins than in patients without liver disease (I СG - affected due to the accident and III СG - persons who are not exposed to accident factors )(p< 0,05-0,001). The increase in average blood glucose in patients with NAFLD were significantly higher than these values in the СG III (p<0.05). The average BMI was greatest in patients with NAFLD main and II СG, significantly differing in II СG and СG III (p < 0.001). Persons with normal weight among patients with NAFLD was significantly less than in the comparison group (p<0.001).Obesity was diagnosed in only 43.3% of the patients of the main group and 54% in II СG. Shown violations of prooxidant-antioxidant balance at different stages in the development of NAFLD: identified changes in the level of compounds with isolated double bonds, the relative content of diene conjugates and obsidianovom conjugates, increasing secondary LPO products - TBA-active products. Average values of factor of antioxidant status in the study group as in patients with SН and NАSH were lower than the corresponding values in the II СG - 29 % and 21 %, respectively. Revealed a relative increase in the diameter of the portal vein with NАSH and SН in the main group and in the SН II СG compared with patients without liver disease (p<0.05). The increase in blood pressure in patients of the main group defined in 51.5% of cases, which was significantly higher than in IСG ( 25%, p < 0.01) and did not differ from the II СG. НD was installed 71,3% of patients of the main group, 58% II СG significantly more often than in I СG (35,7%, p<0.01) and III СG (18,7%, p<0.001). According to the results published 12 papers made 2 of the report on the workshops for doctors. Product Description popup.authors Альохіна С. М. Гасанова О.В. Зелінська А. В. Кадюк О. М. Незговорова Г. А. Носач О. В. Овсяннікова Л. М. Плескач О. Я. Саркісова Е. О. popup.nrat_date 2020-04-02 Close