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Information × Registration Number 0215U008105, 0113U000711 , R & D reports Title To conduct a comparative analysis of the mechanisms of pathology vital organs for experimental seizures different etiology and optimize its pharmacological treatment scheme popup.stage_title Head Kolesova N.A., Registration Date 08-12-2015 Organization National Medical University by Bogomolets popup.description2 In the experiment, 150 rats Wistar with playing two models of seizures (electroconvulsive - ESHSS and korazolovoyi - CIL) and using pathological, histochemical, Electron, biochemical methods of investigation established that the basis of the mechanisms of pathological changes in the heart and kidneys are identical in nature and orientation disorders, but the degree of their development more than ESHSS. The main manifestations of pathological changes in heart were spastic mizhm'yazevyh microvascular changes, changes kontrakturni cardiomyocytes, inhibition of energy metabolism and the development of tissue hypoxia; kidney - and perytubulyarnyh spasm glomerular capillaries, tubules gaps, heterogeneous degenerative and destructive changes tubular epithelium and stromal elements, hipoenerhetyzm. This demonstrates the usefulness of treatment for this disease than anticonvulsants, antihypoxants and antioxidants. Applied pharmacological scheme using lamiktalu, piracetam, alpha-tocopherol causes heart and kidney optimization of energy metabolism and structure; The best results were obtained by CIL treatment, indicating greater severity and partial irreversible pathological changes in ESHSS Product Description popup.authors Брюзгіна Тетяна Семенівна Колесова Надежда Арнольдовна Литвиненко Валентина Іванівна Притула Володимир Андрійович Скрипка Людмила Іванівна Сухарева Надія Миколаївна Черевко Юрій Іванович Чухрай Світлана Миколаївна popup.nrat_date 2020-04-02 Close