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Information × Registration Number 0215U008508, 0110U004997 , R & D reports Title Synthesis, structure and properties of the heteroatom calixarene derivatives for ecological and medical needs popup.stage_title Head Kalchenko Vitaliy Ivanovich, Доктор хімічних наук Registration Date 28-12-2015 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 The objects of the research are: 1) new biologically active calixarenes (thiacalix[4]arenes), functionalized at the upper rim of the macrocycle with biophoric fragments of phosphonic, alfa-hydroxymethylphosphonic, bisphosphonic and alfa-ketophosphonic acids, capable with high selectivity and affinity to form supramolecular complexes with biological targets; 2) calix[n]arenes, modified with amide groups (n = 4, 6) at the lower rim and carbomoilmethylphosphinoxide, phosphonate and phosphineoxide groups (n = 4) at the upper rim of macrocycle, with can be selectively radiotoxic isotopes complexants, and the development of effective sorption materials for the extraction of these isotopes from the wastes of atomic industrial complex and the environmental. Accordingly, the purpose of the work is: 1) the molecular design, synthesis and organization of pilot production of highly selective nanosized calixarene receptors biologically important molecules for the development on their base the modulators of calcium pumps and drug resistance, the enzyme inhibitors, antitrombotics, cardiovascular and anticancer drugs, working bodies of bio- and nanosensors; 2) the development of methods of the synthesis of new radiotoxic isotopes extractants, the study of the structure and properties of the resulting products. The calixarene phosphonous acids synthesized which due to their ability to bind with surface proteins showed a wide spectrum of biologically activity as highly effective inhibitors of phosphatase, inhibitors of fibrin polymerization, calcium channel modulators and modulators of drug resistance. The calixarene phosphonous acids synthesized which due to their ability to bind with surface proteins showed a wide spectrum of biologically activity as highly effective inhibitors of phosphatase, inhibitors of fibrin polymerization, calcium channel modulators and modulators of drug resistance. Also new nanoscale ligands, based on calixareneamides, functionalized with different on nature metals binding groups capable to selectively complexing with cations radiotoxic isotopes were synthesized. Product Description popup.authors Єсипенко Олександр Адольфович Атамась Людмила Іванівна Бойко Вячеслав Іванович Борецький Андрій Леонідович Бретош Катерина Андріївна Вишневський Сергій Григорович Денисенко Ольга Миколаївна Дехтяренко Максим Володимирович Довгоп'ята Лідія Соловеївна Допіра Тетяна Іванівна Драпайло Андрій Богданович Кальченко Віталій Іванович Карпусь Андрій Олегович Лісова Ганна Олексіївна Мірошниченко Станіслав Іванович Матвєєв Юрій Іванович Поліщук Кирило Анатолійович Родік Роман Васильович Рубан Олександр Володимирович Савонік Людмила Мусіївна Святненко Ганна Степанівна Тернова Дарія Сергіївна Харченко Сергій Григорович Хоменко Андрій Валентинович Хорунжа Юлія Леонідівна Черенок Сергій Олексійович Яловіца Віталій Степанович Ямпольська Анна Дмитрівна Ярош Олександр Кузьмич popup.nrat_date 2020-04-02 Close