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Registration Number

0215U008532, 0115U002970 , R & D reports

Title

Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy

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Head

Sidorenko Svitlana Pavlivna, Доктор біологічних наук

Registration Date

28-12-2015

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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We had researched of CD150 isoforms expression with normal (mCD150) and new cytoplasmic (nCD150) domain in normal, malignantly transformed B lymphocytes and also in tumors of central nervous system. Both mCD150 and nCD150 isoforms were detected in normal and malignant B lymphocytes, but level of mCD150 expression in malignant B cell lines was higher than in normal B lymphocytes. Level of nCD150 expression in malignant B cell lines equal to the level of normal B lymphocytes. The mCD150 and nCD150 transcript was also detected in tumors of central nervous system, but in glioma cells nCD150 was found to be the predominant CD150 isoform.

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Гордієнко Інна Михайлівна
Ковалевська Лариса Миколаївна
Сидоренко Світлана Павлівна
Шлапацька Лариса Миколаївна