Search academic texts

Information × Registration Number 0215U008559, 0115U002949 , R & D reports Title The study of the regulatory functions of b - and a-catenin in age and patological reconstruction of the adult myocardium to the needs of personalized medicine and the development of modern methods of prevention, disease diagnosis and treatment of heart diseases popup.stage_title Head Oksana O. Piven, Кандидат біологічних наук Registration Date 29-12-2015 Organization Institute of Molecular Biology and Genetics popup.description2 The investigation of signaling pathways controlling the normal function of the heart and its adaptation to stress is at the edge of modern cardiac biology. Our current work is devoted to the adaptation of the myocardium of wild-type and animals with embryonic cardiospecific haploinsufficiency of b-catenin to physical training, namely smimming. The increase of HW/BW index for trained animals was shown. The increase of hypertrophic genes and Wnt-pathway target genes were detected in both trained and control animals with b-catenin gene haploinsufficiency. Conclusions. The results show that b-catenin gene deficiency leads to fetal (hypertrophic) genes violation even for animals that were not trained. The activation of Wnt-signaling pathway was detected as a result of adult myocardium adaptation to physical stress. These observations point to the conclusion that b-catenin gene function plays important role in the heart adaptation and remodeling during stress. Product Description popup.authors Мацевич Л.Л. Пальчевська О.Л. popup.nrat_date 2020-04-02 Close