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Information × Registration Number 0215U008612, 0115U001379 , R & D reports Title Peculiarities of Ferroplat interaction with structural and functional components of sensitive and resistant tumor cells popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 30-12-2015 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The influence of Ferroplat on pro/antioxidant balance of breast cancer cells with different malignancy levels and different sensitivity to cytostatics was examined. It was found that Ferroplat is capable to redox-regulation of breast cancer cells with different malignancy levels and drug resistance phenotype. All above mentioned is evidence of increase of ROS level, NO generation rate and decrease of antioxidant enzymes activity (superoxide dismutase, glucose-6-phosphate dehydrogenase, level of non-protein thiols) under the influence Ferroplat on these cells. The data indicate that one of the mechanisms of Feroplatu action is a violation of pro/antioxidant balance of tumor cells which is indication of prospects for its use in pathogenetically reasonable target therapy of cancer. Product Description popup.authors Задворний Тарас Володимирович Кунська Любов Миколаївна Лозовська Юлія Валеріївна Лук'янова Наталія Юріївна Павлова Анна Олександрівна Сторчай Дарія Миколаївна Тодор Ігор Миколайович Чехун Василь Федорович Яловенко Тетяна Миколаївна popup.nrat_date 2020-04-02 Close