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Information × Registration Number 0215U008627, 0110U000692 , R & D reports Title Peculiarities of the functioning of mTOR-dependent signaling pathways: the multiplicity of mTOR isoforms and the regulation of metabolic processes in the cell popup.stage_title Head Filonenko Valeriy Viktorovitch, Registration Date 30-12-2015 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 New mTOR kinase isoforms, have been theoretically predicted earlier , were found and characterized in stable cell lines . We obtain specific C-terminal mTOR kinase antibodies. Their usage allow us to detect isoform (g and e) in cell and tissue lysates of different origin at protein level. The analysis of the interaction of S6 kinase 1 (S6K1), a component mTOR-dependent signaling cascade and its new partner protein - TDRD7 was performed. To determine the interaction panel TDRD7 fragments was establishe. It was shown that S6k1 intaract with TDRD7 via its C-terminal, Tudor-containing region Product Description popup.authors Гаріфулін Олег Мінірович Кіямова Рамзія Галямівна Маланчук Оксана Миколаївна Овчаренко Галина Вікторівна Пальчевський Сергій Станіславович Савінська Лілія Олексіївна Скороход Олександр Миколайович Тихонкова Ірина Олександрівна Хоруженко Антоніа Іванівна Чередник Ольга Володимирывна popup.nrat_date 2020-04-02 Close