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Information × Registration Number 0215U009289, 0115U002950 , R & D reports Title Tumor suppressor genes and tumor-associated genes - as potential biomarkers for diagnosis and therapy of malignant tumors popup.stage_title Head Kashuba Vladimir Ivanovich, Доктор біологічних наук Registration Date 18-12-2015 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Collection of prostate carcinomas and paired them normal tissue samples was created. In total there were collected 21 paired tumor - normal samples, including 17 samples of stage II, 3 samples - stage III, and 1 sample - I stage. Total RNA was isolated from these samples and tested for quality. Gene expression for more than 40 tumor-associated genes was investigated on the model prostate cancer cell lines with different potential of invasiveness and metastasis LNCaP, DU145, PC3 compared to normal prostate epithelial cells PNT2. According to the obtained results, differentially expressed genes were selected (EFNA5, TAGLN, TGFB1, IL1B, FOS) as potential markers of invasiveness and metastasis of prostate cancer for further confirmation on clinical samples of tumors.5481 Product Description popup.authors Анопрієнко О.В. Вагіна І.М. Геращенко Ганна Володимирівна Розенберг Є.Е. Строковська Л.І. Чащина Л.І. popup.nrat_date 2020-04-02 Close