Search academic texts

Information × Registration Number 0215U009578, 0113U000067 , R & D reports Title To estimate influence of inflamatory and metabolic risk factors of cardio-vascular diseases on the flow of essential hypertension from data of the proctracted supervision to improve going near its second prophylaxis popup.stage_title Head Svishchenko Yevgeniya Petrivna, Registration Date 14-01-2016 Organization National Scientific Center "Institute of cardiology by M.D. Strazhesko Ukrainian Academy of medical scieces popup.description2 Abstract NIR: 156 pages, 51 tables., 46 picture, 1 appendix, 40 sources. The object of study - essential hypertension (EH), risk factors for cardiovascular complications, target organs. Goal - to improve secondary prevention of essential hypertension on the basis of assessment of the impact of pro-inflammatory and metabolic risk factors for cardiovascular disease in the dynamics of target organ damage during the 10-year follow-up. Methods of research - clinical, biochemical, echocardiography, daily monitoring of blood pressure (BP), duplex scanning of vessels, pathological techniques on models renovascular hypertension on Crawley Chinchilla. It was found that in hypertensive patients progression of organ damage is associated with poor control of blood pressure, increased pulse pressure, the activity of systemic inflammation, initial signs of oxidative stress, the intensification of free radical reactions, autoimmune processes, impaired metabolism of carbohydrates, proteins and purines. Obtained predictors of progression of organ damage, diastolic dysfunction of the left ventricle (LV). Developed regression equation to predict the increase in left ventricular myocardial mass index, the thickness of the intima-media complex of the carotid arteries, a decrease in creatinine clearance 10-year period. Proved corrective action of some antihypertensive drugs and their combinations on the functional state of the left ventricle of the heart hypertensive patients and renal function in patients with hypertensive nephropathy. Reworked model renovascular hypertension in rabbits. Get two declarative patent for an invention, to apply for a declarative patent. ESSENTIAL HYPERTENSION, THE DYNAMICS OF TARGET ORGANS-DAMAGE, THE LEFT VENTRICLE, CAROTID ARTERIES, KIDNEYS, RISK FACTORS.5481 Product Description popup.authors Купчинська Олена Георгіївна Орлова Ніна Миколаївна popup.nrat_date 2020-04-02 Close