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Information × Registration Number 0216U000023, 0113U000291 , R & D reports Title Study influence of long term electrical stimulation on reconstruction of nerves function popup.stage_title Head Tsymbaluk Vitaliy Ivanovich, Registration Date 14-01-2016 Organization State institution ''Institute of Neurosurgery n.acad. AP. Romodanov NAMS of Ukraine'' popup.description2 Object of study: injury of peripheral nerves. Subject matter: clinical manifestation, diagnosis, surgical treatment of peripheral nerves injury combined with chronic invasive electrical stimulation. Methods: neurological examination, EMG. Experimental methods: modeling of sciatic nerve injury in rabbits, nerve suture, implantation of system for chronic invasive electrical stimulation (SCIES); pathomorphology, immune hystochemistry, electronic microscopy were utilized to evaluate the influence of electrical stimulation on muscular and neural apparatus. All results were processed through statistical analysis. The main objective of current study was to resolve the problem of modern neurology and neurosurgery - improvement of peripheral nerve regeneration via chronic invasive electrical stimulation provided by "NeySi-3M" (VEL, Kyiv, Ukraine). The study represents the results of animal experiment and clinical data. Following structural changes of rabbit sciatic nerve (the nerve was sutured and stimulated) revealed: the processes of sciatic nerve regeneration flew quicker. Chronic invasive electrical stimulation in patients with inherited brachial plexus palsy and facial nerve allowed us to achieve "good" outcomes in 76% even in those cases, in which injury of neural structures occurred more than 2 years pre-op. Method of chronic invasive electrical stimulation (developed in our clinic) allowed us strongly improve the results of treatment and achieve positive outcomes (complete, good or moderate recovery) in 79% of patients. On the other hand, single surgical treatment of injuries of abovementioned structures (without chronic electrical stimulation) allowed us to achieve positive results only in 52,9% of patients. The number of "good" outcomes were 2 times higher among patients, who received chronic electrical stimulation (30,7%) than in those, who did not receive one (12,6%). Every fifth patient, who received chronic electrical stimulation (21%), showed no improvement or mild improvement of neurological deficit, on the other hand - every second patient (47,1%) showed the same outcomes without electrical stimulation in post-op period. Chronic invasive electrical stimulation allows physician to shorten the terms of treatment, improves quality of life, thus, has important social and economic meaning. Area of application - neurosurgery. Product Description popup.authors Васлович Вікторія Вікторівна Вербовська Світлана Анатоліївна Гацький Олександр Олександрович Громак Олена Олександрівна Железко Олена Володимирівна Кучерук Олександр Євгенійович Лузан Б.М. Малишева Тетяна Андріївна Татарчук Михайло Михайлович Третяк Ігор Богданович Третякова Альбіна Ігорівна Фрейдман Марк Юрійович Хао Цзян Цимбалюк Юлія Віталіївна Чеботарьова Лідія Львовна popup.nrat_date 2020-04-02 Close