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Registration Number

0216U000031, 0114U001095 , R & D reports

Title

To define the cellular-molecular mechanisms of forming imunopathologiс processes for patients with the diseases of the blood system of myeloid origin

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Head

Alla Gordienko,

Registration Date

15-01-2016

Organization

Kiev Research Institute of Haematolojy and Blood Transfusion

Description

The object of study - 56 patients with MDS and 123 with AML, cells of peripheral blood and bone marrow. Methods: general clinical, hematological, immunological. Established that the mechanism of immunity disorders in patients prior to treatment AML is the expression of CD33+ - blast cells Ligand CD95, that facilitates implementation of FAS-mediated apoptosis of CD4+ -, CD8+ - limfocytic immunoregulatory membrane antigen CD95. Overexpression of intracellular protoonkogen of Bcl-2 in patients with MDS and AML before treatment is an important path of resistance clone of tumor cells. In patients with AML before treatment and MDS in the stage of transformation detected high proliferative activity of tumor cell clone expressing Ki-67, which can be used as an additional criterion for prognosis of the disease. Medical and social effect. Medicine.

Product Description

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Горяінова Н.В.
Кубарова В.О.
Перехрестенко Т.П.
Третяк Н.М.
Шороп Є.В.