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Information × Registration Number 0216U000038, 0115U002148 , R & D reports Title Physico-chemical bases of complex antibacterial preparation creation for sublingual application popup.stage_title Head Romanovska Irina Igorivna, Доктор біологічних наук Registration Date 16-01-2016 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 The interaction of lysozyme with cellulose derivatives, which are essential in formation of the tablet form of enzyme, was established. Acting (lysozyme, chlorhexidine digluconate, Na2EDTA, quercetin) and auxiliary (lactose, mannitol, flavor) components are pharmaceutically compatible. The antimicrobial effect of a complex preparation, which is effective against gram-positive, gram-negative bacteria and fungi was established. For the tableted mass of immobilized lysozyme obtaining, the technology of wet granulation was chosen. The physico-chemical and biochemical properties of the granulate were studied. Product Description popup.authors Є.А. Шестеренко А.М. Овсепян О.В. Севастьянов С.С. Декіна Ю.А. Шестеренко popup.nrat_date 2020-04-02 Close