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Information × Registration Number 0216U000045, 0113U001276 , R & D reports Title Structural and metabolic changes in the cortex of the brain, kidney and liver caused by chronic neoplastic intoxication and components of cytostatic therapy, and their sorption correction popup.stage_title Head Lisnychuk Natalia Yevgenivna, Кандидат біологічних наук Registration Date 16-01-2016 Organization Horbachevsky Ternopil State Medical Academy popup.description2 Significant metabolism disorders, occur in experimental model neoplastic process, are showed by endotoxemia increasing, pronounced changes in cell-mediated and humoral immune system, changes in cytokine profile, development of oxidative stress and functioning imbalance of antioxidant protective factors. Structural changes of kidneys in experimental cancerogenesis, are characterized by microcirculatory alterations in renal corpuscle and peritubular network, destructive changes of epithelial cells in proximal and distal tubules adversely affect phase character of urine formation. In chemically induced colon adenocarcinoma with cytostatic therapy application were revealed dysfunction progression of nonspecific cellular immune factors, further activation of a humoral immunity with active allergization development and CIC accumulation, hyperproduction of pro- and anti-inflammatory cytokines Il-1?, Il-4, Il-6, Il-10, TNF? and significant decreases in Il-2 concentration; increased apoptosis and necrosis activities of CD-3 lymphocytes; pronounced accumulation of lipid peroxidation products and manifestations increased endotoxemia; aggravation of imbalance and enzymatic and glutathione-dependent links of antioxidant system. Chemically induced cancerogenesis and application of cytostatic therapy lead to failure of structural kidney's features in experimental animals. Using of enterosorbent "Carboline" leads to significant decreasing of endotoxicosis, inhibition of prooxidative processes, reduction of functional activity of antioxidant protection links, normalization of kidney's functional state. It was established positive effect of enterosorbtion on state of cell-mediated and humoral immunity. Using enterosorbent "Carboline" for correction of chronic action DMG and components of chemotherapy reduce degree of morphological disturbances of structural kidney's features in experimental animals. Product Description popup.authors Волков Костянтин Степанович Демків Ірина Ярославівна Калінічук Любов Олександрівна Небесна Зоя Михайлівна Чихира Ольга Володимирівна popup.nrat_date 2020-04-02 Close