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Registration Number

0216U000060, 0115U001360 , R & D reports

Title

The mechanisms of the degradation of peroxisomal and cytosolic proteins in the methylotrophic yeast and creation of the overprodusers of proteins with commercial value from mutants with damage of these mechanisms

Head

Sibirny Andriy Andriyovych,

Registration Date

19-01-2016

Organization

Institute of cell biology, National Academy of Sciences of Ukraine

Description

Inactivation of the fructose-1,6-bisphosphatase, formaldehyde dehydrogenase and formate dehydrogenase does not dependent on the duration of glucose starvation. We can make a preliminary conclusion that FBFase degrades both vacuolar and proteasome pathways independently from duration of glucose starvation. Inactivation of the three investigated enzymes in strain with a deletion of the gene GSS1 is delayed, which caused by a decrease of intracellular glucose concentration necessary for catabolite inactivation of these enzymes.5481

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Булботка Ніна Володимирівна
Дмитрук Олена Валеріївна
Левків Катерина Олександрівна
Сибірний Андрій Андрійович